Journal
BMC RESEARCH NOTES
Volume 12, Issue -, Pages -Publisher
SPRINGERNATURE
DOI: 10.1186/s13104-019-4339-4
Keywords
Enterococcus faecalis; Antibiotic resistance; vanA; ermB; aac (6 ')-Ie aph (2 '')
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Funding
- Isfahan University of Medical Sciences [396066]
- Isfahan University of Medical Sciences, Isfahan, Iran
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ObjectivesEnterococcus faecalis as part of the normal floras of human gastrointestinal and genitourinary tracts are an important cause of nosocomial infections. The present study aimed to investigate the prevalence of genes encoding antimicrobial resistance and genetic relatedness of clinical isolates of E. faecalis among Iranian hospitalized patients.ResultsAntibiotic susceptibility testing results indicated that 53 (22.8%) out of 232 E. faecalis isolates were vancomycin resistant (MIC256g/ml). All of the 53 vancomycin-resistant E. faecalis isolates carried the vanA and ermB genes; whereas aac (6)-Ie aph (2), msrA, and ermA gene were found in 96.2%, 30.2% and 3.8% of vancomycin-resistant isolates, respectively. ERIC-PCR typing revealed that 53 vancomycin-resistant isolates were classified into 14 ERIC types. In our results, the high level of resistance to gentamicin, erythromycin and vancomycin in enterococci isolates were mainly related to the presence of aac (6)-Ie aph (2), ermB and vanA genes, respectively. Meanwhile, ERIC-PCR analysis demonstrated that most of the evaluated isolates have a close genetic relatedness.
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