Journal
LANGMUIR
Volume 33, Issue 30, Pages 7393-7402Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.7b01502
Keywords
-
Funding
- National Natural Science Foundation of China [21374088, 21674086]
- Fundamental Research Funds for the Central Universities [3102017jc03006, 3102017jc01001]
Ask authors/readers for more resources
Drug delivery systems based on stimuli-responsive porous polymer films (PPFs) have been extensively investigated because of their many advantages. However, the ability to adjust the drug release from PPFs is not always perfect, and at times, it cannot satisfy real-world requirements. In this paper, supramolecular host-guest interactions were harnessed to overcome the difficulties associated with adjustable release from these systems by incorporating host molecules into the pore walls of thermoresponsive PPFs. beta-Cyclodextrin-functionalized porous amphiphilic block copolymer films (beta-CD-PBCPFs) with controllable pore parameters, high homogeneity, and large areas were prepared by combining the self-assembly and breath-figure methods. Drug-loaded beta-CD-PBCPFs displayed thermoresponsive release behavior, which could be tuned by increasing the beta-CD content in phosphate-buffered saline. The release was governed by the host-guest interactions of the beta-CD moieties and drug molecules. The concept of host-guest interaction-enhanced adjustable release could be applied to different drug molecules, such as doxorubicin and metronidazole.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available