Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 15, Issue 4, Pages 847-856Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.30970
Keywords
long non-coding RNA; PCAT-1; cancer; biomarker; therapeutic target
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Funding
- Shenzhen Project of Science and Technology [JCYJ20170307111748761, 201506042]
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Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides (nts) without obvious protein coding potential. lncRNAs act as multiple roles in biological processes of diseases, especially carcinomas. Prostate cancer associated transcript-1 (PCAT-1) is an oncogenic lncRNA that identified by RNA-Sequence in prostate cancer. High expression of PCAT-1 is observed in different types of cancers, including prostate cancer, colorectal cancer, hepatocellular cancer and gastric cancer. High expressed PCAT-1 is correlated with poor overall survival. Furthermore, PCAT-1 regulates cancer cell proliferation, apoptosis, migration and invasion. Additionally, PCAT-1 is involved in EMT and Wnt/beta-catenin-signaling pathway. In this review, we focus on the implication of PCAT-1 in human cancers.
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