Journal
JACC-BASIC TO TRANSLATIONAL SCIENCE
Volume 4, Issue 3, Pages 385-400Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2019.02.003
Keywords
fatty acid oxidation; heart failure; glucose oxidation; uncoupling of glycolysis
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Alterations in cardiac energy metabolism after a myocardial infarction contribute to the severity of heart failure (HF). Although fatty acid oxidation can be impaired in HF, it is unclear if stimulating fatty acid oxidation is a desirable approach to treat HF. Both immediate and chronic malonyl coenzyme A decarboxylase inhibition, which decreases fatty acid oxidation, improved cardiac function through enhancing cardiac efficiency in a post-myocardial infarction rat that underwent permanent left anterior descending coronary artery ligation. The beneficial effects of MCD inhibition were attributed to a decrease in proton production due to an improved coupling between glycolysis and glucose oxidation. (C) 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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