Nanofat applications: from clinical esthetics to regenerative research Potential applications of nanofat in tissue regeneration with a focus on wound healing and vascularization

Nanofat grafting is a relatively new technique that has gained popularity in esthetic surgery in recent years. Since its discovery, it has emerged as an effective treatment to improve scar quality and attenuate wrinkles. Nanofat is produced through the mechanical shuffling and filtration of microfat, which is harvested by liposuction. It is easily injectable, rich in adipose-derived stem cells, microvascular fragments, and rich in growth factors that, put together, contribute to its pleasing clinical results. Compared with other stem cell-based therapies, harvesting and processing of nanofat is cost-effective as it requires no additional devices or culturing time. Moreover, the liquid consistency of nanofat allows for easy application in a broad range of clinical cases. Hence, we propose that nanofat should also be considered for use in translational research. Based on current techniques in biomaterial loading with stem cells and microvascular fragments, nanofat has the potential to be a valuable alternative to lengthy tissue regeneration protocols in translational research.