Journal
NEURAL REGENERATION RESEARCH
Volume 14, Issue 9, Pages 1530-1535Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.255974
Keywords
sodium butyrate; radioprotector; ionizing radiation; hippocampal damage; cAMP response element binding; brain-derived neurotrophic factor; histone deacetylase inhibitor; neurogenesis
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Funding
- Nuclear Research and Development Program [NRF-2012M2A2A7012377, NRF-2015M2B2B1068627, NRF-2015R1C1A2A01053041]
- National Research Foundation of Korea (NRF) - Korean government Ministry of Science, ICT & Future Planning
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Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain damages. To investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments, adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial irradiation. Cognitive impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after irradiation. We also detected the expression levels of neurogenic cell markers (doublecortin) and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor. Radiation-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. Sodium butyrate pretreatment reversed these changes. These findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression.
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