Journal
LAB ON A CHIP
Volume 17, Issue 7, Pages 1206-1249Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6lc01577h
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Funding
- Medical Research and Development Programs Focused on Technology Transfer: Development of Advanced Measurement and Analysis Systems (SENTAN) - Japan Agency for Medical Research and Development (AMED)
- Research Fellowship of the Japan Society for the Promotion of Science (JSPS)
- Grants-in-Aid for Scientific Research [16J02832] Funding Source: KAKEN
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Microfluidic paper-based analytical devices (mu PADs) have emerged as a promising diagnostic platform a decade ago. In contrast to highly active academic developments, their entry into real-life applications is still very limited. This discrepancy is attributed to the gap between research developments and their practical utility, particularly in the aspects of operational simplicity, long-term stability of devices, and associated equipment. On the basis of these backgrounds, this review attempts to: 1) identify the reasons for success of paper-based devices already in the market, 2) describe the current status and remaining issues of mu PADs in terms of operational complexity, signal interpretation approaches, and storage stability, and 3) discuss the possibility of mass production based on established manufacturing technologies. Finally, the state-of-the-art in commercialisation of mu PADs is discussed, and the upgrades required from a laboratory-based prototype to an end user device are demonstrated on a specific example.
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