Journal
LAB ON A CHIP
Volume 17, Issue 11, Pages 1856-1883Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7lc00242d
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Funding
- Jane and Aatos Erkko Foundation [4704010, 4704482]
- University of Helsinki Research Funds
- Academy of Finland [304844, 297580]
- European Research Council [310892]
- European Research Council (ERC) [310892] Funding Source: European Research Council (ERC)
- Academy of Finland (AKA) [297580, 304844, 297580, 304844] Funding Source: Academy of Finland (AKA)
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The microfluidic technique has brought unique opportunities toward the full control over the production processes for drug delivery carriers, owing to the miniaturisation of the fluidic environment. In comparison to the conventional batch methods, the microfluidic setup provides a range of advantages, including the improved controllability of material characteristics, as well as the precisely controlled release profiles of pay-loads. This review gives an overview of different fluidic principles used in the literature to produce either polymeric microparticles or nanoparticles, focusing on the materials that could have an impact on drug delivery. We also discuss the relations between the particle size and size distribution of the obtained carriers, and the design and configuration of the microfluidic setups. Overall, the use of microfluidic technologies brings exciting opportunities to expand the body of knowledge in the field of controlled drug delivery and great potential to clinical translation of drug delivery systems.
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