Layer-by-layer construction of an oxygen-generating photo-responsive nanomedicine for enhanced photothermal and photodynamic combination therapy

A multifunctional photosensitive and photothermal nanomedicine, AMP- Ce6- HA, was prepared by sequentially layering hard and soft functional molecules. AMP- Ce6- HA was efficiently picked up by MDA- MB- 231 breast cancer cells, and then released oxygen in lysosomes. The photothermal and oxygen- enhanced photodynamic combination therapy was much more effective than the single one.