4.7 Article

Synthesis of chiral seven-membered cyclic sulfonamides through palladium-catalyzed arylation of cyclic imines

Journal

ORGANIC CHEMISTRY FRONTIERS
Volume 6, Issue 10, Pages 1572-1576

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo01323c

Keywords

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Funding

  1. National Natural Science Foundation of China [21772195, 21532006]
  2. Dalian Bureau of Science and Technology [2016RD07]
  3. Chinese Academy of Sciences [XDB17020300, QYZDJ-SSW-SLH035]

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An enantioselective palladium-catalyzed addition of arylboronic acids to seven-membered cyclic N-sulfonyl aldimines and ketimines has been developed, giving the chiral cyclic sulfonamides with excellent yields and up to 99% ee.

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