4.6 Article

Synthesis of multisubstituted arylsulfones via a one-pot, three-component [3+3] benzannulation reaction

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 17, Issue 19, Pages 4753-4760

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob00394k

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Funding

  1. National Natural Science Foundation of China [21772240]
  2. Guangzhou Science Technology and Innovation Commission [201707010210]
  3. Guangdong Province Zhu Jiang Talents Plan [2016ZT06C090]
  4. Nansha District Research Project [2016GJ011]

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A one-pot, three-component [3 + 3] benzannulation reaction of alpha, beta-unsaturated carbonyl compounds, bromoallylic sulfones, and sodium sulfinates had been developed. A series of multisubstituted arylsulfones were prepared with moderate to good yields. This method has the advantages of good step-economy, broad substrate scope and operational simplicity.

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