Journal
LAB ANIMAL
Volume 46, Issue 4, Pages 114-122Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/laban.1222
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Funding
- NIH HHS [K01 OD019924, U42 OD010918] Funding Source: Medline
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The gut microbiota (GM) plays a critical role in human health and disease. Likewise, it is becoming increasingly evident that changes or disruptions to the GM can have significant effects on animal models and their expressed phenotypes, adding a complex and important variable into basic research and preclinical studies. In this article, we review some of the most common sources of GM variability in rodent models, and discuss measures to address this variability for improved reproducibility.
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