Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 37, Pages 5339-5342Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc01688k
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Funding
- German Research Foundation (DFG) under Germany's Excellence Strategy [CIBSS - EXC-2189, 390939984]
- Studienstiftung des deutschen Volkes
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A tunable chemoenzymatic strategy provides access to the entire class of magic spot nucleotides and modified analogues. The approach combines chemoselective bisphosphorylations using phosphoramidites with regioselective ribonuclease T2 cyclo-phosphate hydrolysis, leading to flexible and simple gram-scale operations.
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