4.7 Article

5′-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger

Journal

CHEMICAL COMMUNICATIONS
Volume 55, Issue 35, Pages 5139-5142

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc00977a

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The 5-monophosphate group plays an important role in strand selection during gene silencing mediated by small-interfering RNA. We show that blocking of 5 phosphorylation of the sense strand by introducing a 5-morpholino modification improves antisense strand selection and RNAi activity. The 5-morpholino modification of the antisense strand triggers complete loss of activity.

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