4.7 Article

Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

Journal

CHEMICAL COMMUNICATIONS
Volume 55, Issue 34, Pages 4905-4908

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc01442j

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Funding

  1. National Research Foundation of Korea (NRF) - Korean Government [2015R1C1A1A02037770, 2018R1D1A1A02085552]
  2. Ministry of Food and Drug Safety in 2019 [17162MFDS027]
  3. National Research Foundation of Korea [2018R1D1A1A02085552, 2015R1C1A1A02037770] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.

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