Journal
ISCIENCE
Volume 14, Issue -, Pages 180-+Publisher
CELL PRESS
DOI: 10.1016/j.isci.2019.03.028
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Funding
- NSFC, China [21671122, 21475078, 21805172]
- Taishan Scholar's Construction Project
- Changjiang Scholar Project at SDNU
- Doctoral Fund of Shandong Province [ZR2017BB067]
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Covalent organic frameworks (COFs), an emerging class of organic porous materials, have attracted intense attention due to their versatile applications. However, the deliberate fabrication of COF-based nanomaterials for nanomedical application remains challenging due to difficulty in their size- and structure-controlled synthesis and poor aqueous dispersibility. Herein, we report two boron-dipyrromethene (BODIPY)-decorated nanoscale COFs (NCOFs), which were prepared by the Schiff-base condensation of the free end -CHO (bonding defects in COFs) on the established iminebased NCOFs with the amino-substituted organic photosensitizer BODIPY via bonding defects functionalization approach. Thus BODIPY has been successfully nanocrystallized via the NCOF platform, and can be used for photodynamic therapy (PDT) to treat tumors. These NCOF-based PDT agents featured nanometer size (similar to 110 nm), low dark toxicity, and high phototoxicity as evidenced by in vitro and in vivo experiments. Moreover, the bonding defects functionalization approach might open up new avenues for the fabrication of additional COF-based platforms for biomedical treatment.
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