Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 29, Pages 4270-4272Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc01642b
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Funding
- Russian Foundation for Basic Research [18-03-01029, 19-03-00053]
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A novel approach for monitoring the biomolecular interactions of superparamagnetic nanoparticles was disclosed. Based on ultrafiltration of a human serum-nanoparticle mixture and the mass spectrometric analysis of filtrates, this assay revealed for iron oxide nanoparticles coated with poly(acrylic acid) satisfactory biopersistence and a bimodal binding to sulfur-containing biomolecules, with the formation of the protein corona completed in about 1 h.
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