Journal
KIDNEY & BLOOD PRESSURE RESEARCH
Volume 42, Issue 6, Pages 1164-1174Publisher
KARGER
DOI: 10.1159/000485863
Keywords
Type 2 diabetes; Diabetic kidney disease; EGFR; Interleukin-10; Polymorphism
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brasilia, Brazil [303816/2014-7]
- Fundo de Incentivo a Pesquisa e Eventos do HCPA (FIPE-HCPA), Porto Alegre, Brazil [14-0645]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
- CNPq
Ask authors/readers for more resources
Background/Aims: The -1082A>G polymorphism (rs1800896) in the interleukin-10 (IL10) gene has been associated with type 2 diabetes and diabetic retinopathy, but its relationship with diabetic kidney disease (DKD) is uncertain. The aim of this case-control study was to investigate whether the -1082A> G polymorphism is associated with DKD in white Brazilians with type 2 diabetes mellitus. Methods: Genotyping was done by real-time polymerase chain reaction for 597 type 2 diabetic outpatients. The definition of DKD was based on estimated glomerular filtration rate (eGFR) and albuminuria, and the patients were grouped in three categories: no DKD (n= 249), mild to moderate DKD (n= 222), and severe DKD (n= 126). Results: The frequency of the minor (G) allele in subjects without DKD did not differ from that observed in subjects with DKD (0.35 vs 0.39, respectively; P = 0.192). Genotype frequencies in subjects without DKD were not significantly different from those observed among patients with mild to moderate DKD or severe DKD. However, considering only the eGFR categories as an indicator of renal function, the AG genotype was independently associated with an increased risk of mildly to moderately decreased eGFR (G3a category) and GG genotype was independently associated with increased risk of kidney failure (G5 category) as compared with AA genotype. Conclusion: Our findings support the hypothesis that the -1082A> G polymorphism in the IL10 gene might be associated with DKD in white Brazilians with type 2 diabetes. (C) 2017 The Author(s) Published by S.Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available