Journal
RSC ADVANCES
Volume 9, Issue 25, Pages 14011-14015Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra00780f
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Funding
- Scientific and Technological Research Council of Turkey (TUBITAK) under International Support Program (COST Action - European Cooperation in Science and Technology) [CA15216, 116M995]
- Presidency of Turkey, Presidency of Strategy and Budget
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An ultrafast and convenient method for PEGylation of chitosan nanoparticles has been established through a photopolymerization reaction between the acrylate groups of PEG and methacrylated-chitosan nanoparticles. The nanoparticle characteristics under physiological pH conditions were optimized through altered PEG chain length, concentration and duration of UV exposure. The method developed here has potential for clinical translation of chitosan nanoparticles. It also allows for the scalable and fast synthesis of nanoparticles with colloidal stability.
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