Journal
THERANOSTICS
Volume 9, Issue 11, Pages 3249-3261Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.31814
Keywords
peptides; self-assembly; intermolecular interactions; nanotheranostics; cancer
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Funding
- National Natural Science Foundation of China [21773248, 21802144]
- National Natural Science Fund BRICS STI Framework Programme [51861145304]
- Innovation Research Community Science Fund [21821005]
- Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) [QYZDB-SSW-JSC034]
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Advances in supramolecular self-assembly have promoted the development of theranostics, the combination of both therapeutic and diagnostic functions in a single nanoplatform, which is closely associated with antitumor applications and has shown promising potential in personalized medicine. Peptide-modulated self-assembly serves as a versatile strategy for tumor supramolecular nanotheranostics possessing controllability, programmability, functionality and biosafety, thus promoting the translation of nanotheranostics from bench to bedside. In this review, we will focus on the self-assembly of peptide-photosensitizers and peptide-drugs as well as multicomponent cooperative self-assembly for the fabrication of nanotheranostics that integrate diagnosis and therapeutics for antitumor applications. Emphasis will be placed on building block design, interaction strategies and the potential relationships between their structures and properties, aiming to increase understanding of the critical role of peptide-modulated self-assembly in advancing antitumor supramolecular nanotheranostics.
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