Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 72, Issue 10, Pages 1431-1436Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glw330
Keywords
Brain aging; Antioxidant; Nutrition
Categories
Funding
- Atlantic Philanthropies
- Irish Government
- Irish Life plc
- Centre for Ageing Research and Development in Ireland (CARDI)
- Waterford Institute of Technology
- Bayer Ireland
- European Research Council
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Background: Low blood serum or plasma concentrations of the xanthophyll carotenoids lutein and zeaxanthin have been implicated in poorer cognitive health in older adults. However, equivocal results from smaller studies and clinical trials highlight the need for large population-based studies with comprehensive measures of cognitive function and adjustment for multiple confounders to examine such associations in more depth. Methods: In the current study, we investigated the association between plasma lutein and zeaxanthin and domain-specific cognitive performance in 4,076 community-dwelling adults aged 50 years or older from The Irish Longitudinal Study on Ageing. Mixed-effects models were fitted with adjustment for demographic and socioeconomic factors, health conditions, and health behaviors. Results: Higher plasma lutein and zeaxanthin were independently associated with better composite scores across the domains of global cognition, memory, and executive function. We also found evidence that higher plasma zeaxanthin, but not lutein, was associated with better processing speed. These associations were consistent across domains. Conclusions: Further investigation of the prognostic value of carotenoid concentrations, and their changes, on cognition in similar populationbased samples longitudinally is warranted.
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