4.6 Article

Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells

Journal

RSC ADVANCES
Volume 9, Issue 24, Pages 13372-13377

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra01948k

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Funding

  1. SUT Research and Development Fund

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AZB-IMC2 was developed as a COX-2 specific probe that exhibited a brighter fluorescence signal in cancer cells that overexpress COX-2 compared to normal cells. Oxidative stress agent-treated inflamed cell lines inducing high COX-2 levels revealed an enhanced fluorescence signal. Inhibitory studies showed a markedly reduced fluorescence intensity in cancer cells. The results suggested that AZB-IMC2 could be developed as a promising molecular tool for imaging guiding during surgery.

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