Journal
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
Volume 18, Issue 4, Pages 277-288Publisher
ZHEJIANG UNIV
DOI: 10.1631/jzus.B1600460
Keywords
Herpes simplex virus type 1; Adaptive immunity; T cells; Vaccine
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Funding
- Wuhan Institute of Virology (WIV) One-Three-Five Strategic Programs, China
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Herpes simplex virus type 1 (HSV-1), a neurotropic member of the alphaherpes virus family, is among the most prevalent and successful human pathogens. HSV-1 can cause serious diseases at every stage of life including fatal disseminated disease in newborns, cold sores, eye disease, and fatal encephalitis in adults. HSV-1 infection can trigger rapid immune responses, and efficient inhibition and clearance of HSV-1 infection rely on both the innate and adaptive immune responses of the host. Multiple strategies have been used to restrict host innate immune responses by HSV-1 to facilitate its infection in host cells. The adaptive immunity of the host plays an important role in inhibiting HSV-1 infections. The activation and regulation of T cells are the important aspects of the adaptive immunity. They play a crucial role in host-mediated immunity and are important for clearing HSV-1. In this review, we examine the findings on T cell immune responses during HSV-1 infection, which hold promise in the design of new vaccine candidates for HSV-1.
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