Journal
MEDCHEMCOMM
Volume 10, Issue 5, Pages 806-813Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9md00155g
Keywords
-
Funding
- CSIR, New Delhi
- UGC, New Delhi
- SERB-NPDF [PDF/2017/001556]
Ask authors/readers for more resources
A series of new 1,4-dihydroindeno.1,2-c] pyrazole tethered carbohydrazide hybrids (5a-u) were designed, synthesized and evaluated for their antimicrobial activity. Compounds 5d, 5g, 5j, 5k and 5q demonstrated significant activity against the entire panel of test pathogens. Further, compounds 5d and 5g exhibited significant anti-Candida activity. These potential hybrids (5d and 5g) also exhibited promising ergosterol biosynthesis inhibition against Candida albicans, which was further validated through molecular docking studies. Furthermore, compounds 5d and 5g caused intracellular ROS accumulation in C. albicans MTCC 3017 and were non-toxic to normal human lung cell line MRC5. In silico studies revealed that they demonstrated drug likeness and an appreciable pharmacokinetic profile. Overall, the findings demonstrate that 5d and 5g may be considered as promising leads for further development of new antifungal drugs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available