Journal
INFLAMMATION AND REGENERATION
Volume 39, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s41232-019-0101-5
Keywords
Interleukin-1; Metabolic inflammation; Inflammatory diseases; Cancer; Drug target
Categories
Funding
- Japan Society for the Promotion of Science (JSPS) [17H04656, 17 K19685]
- Grants-in-Aid for Scientific Research [17H04656] Funding Source: KAKEN
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Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 family members have been expanding and evidence is accumulating that highlights the importance of interleukin-1 in linking innate immunity with a broad spectrum of diseases beyond inflammatory diseases. In this review, we look back on the definition of inflammation in traditional general pathology and discuss new insights into interleukin-1 in view of its history and the molecular bases of diseases, as well as current progress in therapeutics.
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