Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 45, Pages 6453-6456Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc01850f
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Funding
- National Natural Science Foundation (NNSF) of China [21775124, 21575116, 21675129]
- Fundamental Research Funds for the Central Universities [XDJK2018AA0003]
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In this work, a novel fluorescent assay was proposed for the ultrasensitive detection of microRNA- 21 (miRNA- 21) based on the efficient immobilization of protoporphyrin IX (PPIX) as signal indicators in massive G- quadruplex structures obtained by target recycling, three- dimensional DNA walker and a rolling circle amplification (RCA) coupled cascade nucleic acid amplification strategy.
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