Journal
FOOD & FUNCTION
Volume 10, Issue 5, Pages 2785-2796Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9fo00234k
Keywords
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Funding
- National Natural Science Foundation of China [31701722]
- Modern Agricultural Industry Technology System [CARS-30]
- National Key R&D Program of China [2017YFE0105300]
- Key Research and Development Plan of Shaanxi Province [2017ZDXL-NY-0304]
- China Postdoctoral Science Foundation [2017M620471]
- Shaanxi Provincial Natural Science Foundation [2018JQ3054]
- Postdoctoral Research Project of Shaanxi Province [2017BSHEDZZ103]
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Deoxynivalenol (DON) is a mycotoxin that contaminates grains and feed. Degradation and toxicity reduction of DON by probiotics benefit human and animal health. Lactobacillus rhamnosus is an FDA-approved probiotic that can be used in children. After screening seven L. rhamnosus strains isolated from human milk, SHA113 showed the highest DON degradation rate of 60% under the optimal conditions of 37 degrees C, pH 6.0, OD600 = 1.5, 5 mg L-1 DON, and 48 h. When dead and live SHA113 cells were used separately, only the live cells reduced the DON concentration and transformed it into 3-epi-DON. Mice feeding experiments showed that pretreatment with SHA113 for 48 h reduced the toxicity of DON to the immunological system and organs. Directly feeding SHA113 cells could also slightly reduce the DON toxicity. Both in vitro and in vivo experiments indicated that L. rhamnosus has potential to reduce DON toxicity.
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