Journal
JOURNAL OF VIROLOGY
Volume 91, Issue 16, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01667-16
Keywords
cancer; human herpesviruses; immune evasion; immune surveillance; microRNA
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Funding
- Deutsche Forschungsgemeinschaft [SFB1064/TP A13, SFB-TR36/TP A04]
- Deutsche Krebshilfe [107277, 109661]
- National Cancer Institute [CA70723]
- Deutscher Akademischer Austauschdienst (DAAD) (Studienstipendien fur auslandische Graduierte aller wissenschaftlichen Facher)
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Epstein-Barr virus (EBV) has established lifelong infection in more than 90% of humanity. While infection is usually controlled by the immune system, the human host fails to completely eliminate the pathogen. Several herpesviral proteins are known to act as immunoevasins, preventing or reducing recognition of EBV-infected cells. Only recently were microRNAs of EBV identified to reduce immune recognition further. This Gem summarizes what we know about immunomodulatory microRNAs of herpesviruses.
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