Journal
ENDOCRINE JOURNAL
Volume 66, Issue 5, Pages 423-430Publisher
JAPAN ENDOCRINE SOC
DOI: 10.1507/endocrj.EJ18-0396
Keywords
Hashimoto's thyroiditis; Graves' disease; Interleukin-17; Interleukin-23; Interleukin-1 beta
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Funding
- Latvian National Research Program BIOMEDICINE [5.2.4]
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T helper (Th) 17 cells and interleukin (IL)-17 play a significant role in the pathogenesis of autoimmune thyroid disease (AITD). However, it has recently become clear that Th17 cells are more heterogeneous and exhibit two different phenotypes, whereas IL-23 and IL-1 beta are crucial for the generation of pathogenic Th17 lymphocytes. We aimed to investigate the association between IL-17 and Th17-promoting cytokines in AITD by studying the immunoexpression patterns of IL-17, IL-23, and IL-1 beta in thyroid tissue. Following thyroidectorny, 29 patients with AITD (21 cases of Hashimoto's thyroiditis (HT) and 8 cases of Graves' disease (GD)) and 18 patients with colloid goiter, as controls, were enrolled in this study, and immunohistochemistry was performed. The expression level of IL-17 in thyrocytes was significantly higher in HT and GD patients than in colloid goiter patients. Immunopositivity for both IL-23 and IL-1 beta was significantly increased in HT patients compared to GD and colloid goiter patients. However, no difference was found between IL-23 or IL-1 beta expression in patients with GD and colloid goiter. A positive correlation between IL-17 and IL-23 as well as IL-17 and IL-1 beta expression was observed in HT patients (r = 0.574, p = 0.007 and r = 0.461, p = 0.036, respectively). In the GD group, IL-17 was positively correlated with IL-1 beta (r = 0.817, p = 0.013) but not with IL-23 expression. We found increased IL-23 and IL-1 beta expression in the HT group but not in the GD group. Furthermore, both interleukin were correlated with IL-17 immunopositivity in thyroid tissue, suggesting that pathogenic Th17-promoting cytokines may play a role in HT pathogenesis.
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