Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 44, Pages 6165-6168Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc01728c
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Funding
- Japan Agency for Medical Research and Development (AMED) [JP19dm0307030, JP18jm0210058]
- Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) [JP18dm0207014]
- JSPS KAKENHI [JP17H01522, JP17K19479, JP16H06216, JP16K15229, JP19H01015, JP18K06653]
- Tokyo Biochemical Research Foundation
- Research Foundation for Opto-science and Technology
- Takeda Science Foundation
- Asahi Glass Foundation
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Tau amyloid formation and deposition are responsible for the onset of Alzheimer's disease. In particular, the seeding activity of the tau protein plays an important role in the spreading of tau pathology via its propagation in the human brain. Here we demonstrate that catalytic photo-oxygenation markedly suppresses tau seeding activity, resulting in the inhibition of amyloid formation, both in vitro and in cultured cells.
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