Journal
JOURNAL OF VETERINARY MEDICAL SCIENCE
Volume 79, Issue 7, Pages 1272-1277Publisher
JAPAN SOC VET SCI
DOI: 10.1292/jvms.17-0229
Keywords
cancer; canine; immunohistochemical staining; Wilms' tumor 1
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Funding
- Ministry of Education, Science, Sports and Culture of Japan
- Grants-in-Aid for Scientific Research [16K08051] Funding Source: KAKEN
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Wilms' tumor 1 (WT1) expression has been investigated in various human cancers as a target molecule for cancer immunotherapy. However, few studies have focused on WT1 expression in dogs. Firstly, cDNA of canine WT1 (cWT1) was molecularly cloned from normal canine kidney. The cross-reactivity of the anti-human WT1 monoclonal antibody (6F-H2) with cWT1 was confirmed via Western blotting using cells overexpressing cWT1. Immunohistochemical staining revealed that cWT1 expression was detected in all canine lymphoma tissues and in some normal canine tissues, including the kidney and lymph node. cWT1 is a potential immunotherapy target against canine cancers.
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