Journal
ACS APPLIED BIO MATERIALS
Volume 2, Issue 6, Pages 2347-2354Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.9b00046
Keywords
nalidixic acid; antimicrobial activity; metal-organic frameworks; antibiotics; mechanochemistry
Funding
- Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) [PEst-OE/QUI/UI0100/2013]
- FEDER [PTDC/QUI-OUT/30988/2017]
- FCT/MEC [POCI-01-0145-FEDER-007679, UID/CTM/50011/2013]
- FEDER under the PT2020 Partnership Agreement
- Fundação para a Ciência e a Tecnologia [PTDC/QUI-OUT/30988/2017] Funding Source: FCT
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The development of metal-organic frameworks (MOFs) enclosing active pharmaceutical ingredients is of considerable interest, as their use in controlled drug release and delivery is very promising. Although nalidixic acid is an antibiotic with a broad spectrum of biological applications, effective mainly against Gram-negative infections, its oral bioavailability is low due to a poor solubility and slow dissolution. Herein, we report new metal-organic frameworks (BioMOFs) comprising nalidixic acid and divalent magnesium and manganese ions. These compounds showed an adequate cytotoxicity and improved antimicrobial activity, especially against Gram-negative bacteria. These BioMOFS are among the first examples containing active pharmaceutical ingredients as linkers. Importantly, it is shown that a remarkable increase of the antimicrobial activity of certain antibiotics may be achieved by delivering them in the form of BioMOFs.
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