Journal
THERANOSTICS
Volume 9, Issue 12, Pages 3653-3658Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.31032
Keywords
MALT lymphoma; PET; CXCR4; [Ga-68]-Pentixafor; PET/MRI
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Funding
- NCI NIH HHS [P30 CA008748] Funding Source: Medline
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MALT lymphomas express the chemokine receptor CXCR4 on a regular basis, and [Ga-68]Ga-Pentixafor-PET has been shown to quantify CXCR4 expression non-invasively. We, therefore, aimed to evaluate [Ga-68]Ga-Pentixafor-PET/MRI for the non-invasive assessment of MALT lymphomas. Methods: We included 36 MALT lymphoma patients, who had not undergone previous systemic or radiation therapy, in our prospective, IRB-approved, proof-of-concept study. Involved anatomic regions were the orbit (n=14), stomach (n=10), lungs (n=5), and other sites (soft-tissues n=3; adrenal gland, tonsils, parotid gland, and urinary bladder n=1, respectively). MRI sequences included an axial 2-point Dixon T1 VIBE SPAIR 3D sequence for PET attenuation correction; a coronal T2 HASTE sequence; and an axial echo-planar imaging SPAIR-based diffusion-weighted sequence (DWI) obtained during free-breathing (b-values, 50 and 800), with corresponding ADC (apparent diffusion coefficient) maps. Results: In 33/36 patients, there were MALT lymphomas with an increased uptake of [Ga-68]Ga-Pentixafor; all current lymphoma manifestations showed an increased uptake and, accordingly, were positive on the PET/MRI. The remaining three patients had undergone surgery for their orbital MALT lymphomas prior to PET/MRI. Mean SUVmax was 8.6 +/- 4.7, mean SUVmean was 4.7 +/- 1.8, and mean SUVpeak was 8.0 +/- 4.2. The mean SUVmax of the liver was 1.8, and the mean tumor-to-liver ratio was 2.9 +/- 2.0. There were no significant differences in SUVmax (P=0.22), SUVmean (P=0.53), SUVpeak (P=0.29), or SUVt/I (P=0.92) between the four anatomic regions (orbit, stomach, lungs, other). The mean tumor volume was 146 +/- 499. Conclusions: Our results thus indicate that [Ga-68]Ga-Pentixafor-PET is feasible for the assessment of MALT lymphomas, with a good tumor-to-background ratio in terms of radiotracer uptake.
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