Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 6, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2018.1537709
Keywords
Renal carcinoma; oncometabolite; fumarate hydratase; mTOR; fumarate
Categories
Funding
- Associazione Italiana per la Ricerca sul Cancro [IG18706, IG14382]
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Modeling renal cancer in the mouse has been challenging. We recently showed that upregulation of mechanistic target of rapamycin complex 1 (mTORC1) in a restricted segment of the renal tubule leads to downregulation of the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase, to accumulation of the oncometabolite fumarate, and gradual transformation from benign cysts into cystadenomas and papillary carcinomas.
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