Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 6, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2018.1511205
Keywords
prostate cancer; mouse model; senescence; replicative stress; DNA damage
Categories
Funding
- Centre National de la Recherche Scientifique
- Fondation ARC pour la Recherche sur le Cancer
- Institut National de la Sante et de la Recherche Medicale
- Ligue Contre le Cancer
- Ministere de l'Enseignement superieur, de la Recherche et de l'Innovation
- Association pour la Recherche a l'IGBMC (ARI)
- French state funds through the Agence Nationale de la Recherche [ANR-10-LABX-0030-INRT, ANR-10-IDEX-0002-02]
- Centre d'Ingenierie Moleculaire Europeen
- Association pour la Recherche sur les Tumeurs de la Prostate
- Al Bizri foundation
- Alsace Contre le Cancer
- Universite de Strasbourg
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We report that Pten (phosphatase and tensin homologue) ablation in prostatic epithelial cells of adult mice promotes cell proliferation to generate prostatic intraepithelial neoplasia. Moreover, our results demonstrate that proliferating Pten-deficient cells undergo replication stress and exhibit a DNA damage response, leading to cell senescence, as seen in oncogene-induced senescence.
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