Journal
EARLY HUMAN DEVELOPMENT
Volume 91, Issue 11, Pages 643-647Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.earlhumdev.2015.08.008
Keywords
Glucocorticoids; Corticosterone; Ageing; Longevity; Telomeres; Hormesis
Categories
Funding
- Leverhulme Trust [VP2-2013-032]
- BBSRC [BB/J015091/1]
- National Science Foundation [IOS-1145625]
- European Research Council [ERC AdG 268926]
- BBSRC [BB/J015091/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/J015091/1] Funding Source: researchfish
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1146569] Funding Source: National Science Foundation
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We discuss the long-term effects of stress exposure in pre- and early postnal life. We present an evolutionary framework within which such effects can be viewed, and describe how the outcomes might vary with species life histories. We focus on stressors that induce increases in glucocorticoid hormones and discuss the advantages of an experimental approach. We describe a number of studies demonstrating how exposure to these hormones in early life can influence stress responsiveness and have substantial long-term, negative consequences for adult longevity. We also describe how early life exposure to mild levels of stressors can have beneficial effects on resilience to stress in later life, and discuss how the balance of costs and benefits is likely dependent on the nature of the adult environment (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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