Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 48, Pages 6827-6830Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc02939g
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Funding
- National Natural Science Foundation of China [21527811, 21735003, 21605098]
- Award for Team Leader Program of Taishan Scholars of Shandong Province, China
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We develop a new fluorescent method for sensitive detection of long noncoding RNAs (lncRNAs) on the basis of duplex-specific nuclease-actuated cyclic enzymatic repairing-mediated signal amplification. This method exhibits high sensitivity with a detection limit of 0.081 fM, and it can accurately detect the endogenous lncRNA HOTAIR in cancer cells, providing a new approach to study the physiological function of lncRNAs in human diseases.
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