Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 7, Issue 17, Pages 2759-2765Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb00338j
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Funding
- National Natural Science Foundation of China [51872188, 81701827]
- Shenzhen Basic Research Program [JCYJ20170302151858466, JCYJ20170818093808351, GJHZ20180418190532315]
- Shenzhen Peacock Plan [KQTD2016053112051497]
- Natural Science Foundation of SZU [827-000143]
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Hydrogen therapy is an emerging and promising strategy for treatment of inflammation-related diseases owing to the excellent bio-safety of hydrogen molecules (H-2), but is facing a challenge that the H-2 concentration at the local disease site is hardly accumulated because of its high diffusibility and low solubility, limiting the efficacy of hydrogen therapy. Herein, we propose a nanomedicine strategy of imaging-guided tumour-targeted delivery and tumour microenvironment-triggered release of H-2 to address this issue, and develop a kind of biocompatible carboxymethyl cellulose (CMC)-coated/stabilized Fe (Fe@CMC) nanoparticle with photoacoustic imaging (PAI), tumour targeting and acid responsive hydrogen release properties for cancer therapy. The Fe@CMC nanoparticles have demonstrated high intratumoural accumulation capability, high acid responsiveness, excellent PAI performance, selective cancer-killing effect and high bio-safety in vitro and in vivo. Effective inhibition of tumour growth is achieved by intravenous injection of the Fe@CMC nanoparticles, and the selective anti-cancer mechanism of Fe@CMC is discovered to be originated from the energy metabolism homeostasis regulatory function of the released H-2. The proposed nanomedicine-mediated hydrogen therapy strategy will open a new window for precise, high-efficacy and safe cancer treatment.
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