4.7 Article

A consecutive process for C-C and C-N bond formation with high enantio-and diastereo-control: direct reductive amination of chiral ketones using hydrogenation catalysts

Journal

CHEMICAL COMMUNICATIONS
Volume 55, Issue 45, Pages 6409-6412

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc00923j

Keywords

-

Funding

  1. University of St Andrews
  2. EPSRC Centre for Doctoral Training in Critical Resource Catalysis (CRITICAT) [EP/L016419/1]

Ask authors/readers for more resources

High diastereoselectivity was observed in the Rh-catalysed reductive amination of 3-arylcyclohexanones to form tertiary amines. This was incorporated into a one-pot enantioselective conjugate addition and diastereoselective reductive amination, including an example of assisted tandem catalysis.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available