Journal
FRONTIERS IN MICROBIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2019.01425
Keywords
HIV; HEV; epidemiology; zoonoses; treatment; prevention; diagnosis
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Funding
- Ministry of Economy and Competitiveness [RD12/0017/0012]
- European Regional Development Fund
- Health Research Fund from the Institute of Health Carlos III (ISCIII) [PI16/01297]
- SPANISH AIDS Research Network [RD16/0025/0034 - ISCIII - FEDER]
- Miguel Servet Research Contract by Ministerio de Ciencia, Promocion y Universidades of Spain [CP18/00111]
- Sara Borrell Research Contract Program by the Ministerio de Ciencia, Promocion y Universidades of Spain [CD18/00091]
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Background: The hepatitis E virus (HEV) represents a major cause of acute hepatitis worldwide. The majority of HEV cases occur in low-income countries, mainly Asia and Africa, where HEV causes large outbreaks associated with the consumption of contaminated water and high mortality in specific populations. In high-income countries, HEV infection is considered a zoonotic disease that is linked to the consumption of contaminated food. Although a high proportion of cases have self-limiting asymptomatic or subclinical infections, immunosuppression may modify the pathogenesis and clinical impact of this emerging disease. Results and Discussion: Here, we review the current knowledge about the epidemiology, diagnosis, clinical manifestations, management and prevention of HEV infection in HIV-infected subjects. Conclusions: Despite the increasing knowledge about the pathogenesis, epidemiology and clinical impact of HEV infection, several major factors are faced by HIV-infected patients, including treatment recommendations, immunization and risk practices.
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