Journal
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Volume 11, Issue 12, Pages 3544-3555Publisher
WILEY
DOI: 10.1002/term.2272
Keywords
scaffolds; microspheres; curcumin; infection; full-thickness burn; wound healing
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Funding
- Natural Science Foundation of China [51303064, 81171812, 81272105]
- PhD Programs Foundation of the Ministry of Education of China [20124401120015]
- National Basic Science and Development Program (973 Program) [2012CB518105]
- Health and Medical Treatment Collaborative Innovation Major Special Projects of Guangzhou [201508020253]
- Science and Technology Program of Guangzhou [201601010270]
- Science and Technology Project of Guangdong province [2011B031300006, 2015A010101313]
- Science and Technology key Project of Guangdong province [2014B020212010]
- Leading Talents of Guangdong Province [87014002]
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Burn infection is a serious problem that delays wound healing and leads to death. Curcumin (Cur) has been shown to exhibit antioxidant, anti-inflammatory, antimicrobial and anticarcinogenic activity. However, its instability, extremely low aqueous solubility and bioavailability in physiological fluids may make it difficult to maintain local Cur concentrations above the minimum inhibitory concentration for burn infection treatment. The objective of this study was to construct complexes of Cur/gelatin microspheres (GMs) and porous collagen (Coll)-cellulose nanocrystals (CNCs) composite scaffolds for full-thickness burn infection treatment. The Cur/GMs/Coll-CNCs scaffolds had high porosity, available pore size, and a long and sustained Cur release profile. Furthermore, the composite scaffold exhibited remarkably strong antibacterial activity. Hence, we evaluated the wound-healing effects and antibacterial properties of Cur/GMs/Coll-CNCs scaffolds in a rat full-thickness burn infection model. The Cur/GMs/Coll-CNCs scaffold was able to prevent not only local inflammation but also accelerated dermis regeneration. Thus, we conclude that Cur/GMs/Coll-CNCs scaffolds can act as an effective dermal regeneration template for full-thickness burn wound infection healing in rats models. Copyright (c) 2017 John Wiley & Sons, Ltd.
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