Journal
BRIEFINGS IN BIOINFORMATICS
Volume 20, Issue 4, Pages 1160-1166Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bib/bbx108
Keywords
multiple sequence alignment; sequence analysis; phylogenetic tree
Funding
- Japan Society for the Promotion of Science (JSPS) KAKENHI [JP16K07464]
- Platform Project for Supporting Drug Discovery and Life Science Research from Japan Agency for Medical Research and Development (AMED)
- Grants-in-Aid for Scientific Research [16K07464] Funding Source: KAKEN
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This article describes several features in the MAFFT online service for multiple sequence alignment (MSA). As a result of recent advances in sequencing technologies, huge numbers of biological sequences are available and the need for MSAs with large numbers of sequences is increasing. To extract biologically relevant information from such data, sophistication of algorithms is necessary but not sufficient. Intuitive and interactive tools for experimental biologists to semiautomatically handle large data are becoming important. We are working on development of MAFFT toward these two directions. Here, we explain (i) the Web interface for recently developed options for large data and (ii) interactive usage to refine sequence data sets and MSAs.
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