Journal
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume 16, Issue 2, Pages 220-230Publisher
WILEY
DOI: 10.1111/jth.13910
Keywords
hemostasis; negative regulators; platelet adhesion; platelet reactivity; thrombosis
Categories
Funding
- American Heart Association [14EIA18910004]
- NIH [HL121650, HL130404]
- Young Researchers Program Rita Levi Montalcini
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL120846, R01HL133668, R01HL130404, R01HL121650] Funding Source: NIH RePORTER
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Platelets are small anucleated cells that constantly patrol the cardiovascular system to preserve its integrity and prevent excessive blood loss where the vessel lining is breached. Their key challenge is to form a hemostatic plug under conditions of high shear forces. To do so, platelets have evolved a molecular machinery that enables them to sense trace amounts of signals at the site of damage and to rapidly shift from a non-adhesive to a pro-adhesive state. However, this highly efficient molecular machinery can also lead to unintended platelet activation and cause clinical complications such as thrombocytopenia and thrombosis. Thus, several checkpoints are in place to tightly control platelet activation and adhesiveness in space and time. In this review, we will discuss select negative regulators of platelet activation, which are critical to maintain patrolling platelets in a quiescent, non-adhesive state and/or to limit platelet adhesion to sites of injury.
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