Journal
DYES AND PIGMENTS
Volume 120, Issue -, Pages 22-29Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2015.03.022
Keywords
Fluorescent probe; Hypochlorite; Fluorescein derivative; Endogenous imaging; CN isomerization; Formylated fluorescein
Funding
- National Natural Science Foundation of China [21376117, 81371684]
- Jiangsu Natural Science Funds for Distinguished Young Scholars [BK20140043]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [14KJA150005]
- Qing Lan Project
- Project of Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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A new fluorescein-based probe is found to be sensitive and selective for the detection of hypochlorite anion in aqueous buffer solution. The probe displays high water solubility, pH-independent fluorescence, and biocompatibility. A possible detection mechanism is that HOCl oxidizes the C=N bond into aldehyde, resulting in bright emission. Results show that the probe has a 7.3 nM detection limit to hypochlorite anion. In addition, the probe is successfully utilized for monitoring endogenously produced hypochlorite in living macrophage cells upon stimulation. (C) 2015 Elsevier Ltd. All rights reserved.
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