Journal
NATURE REVIEWS CANCER
Volume 19, Issue 7, Pages 405-414Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41568-019-0149-1
Keywords
-
Categories
Funding
- Rudolf Virchow Center, University of Wurzburg
- FWO-Flanders [1506218 N, 1507118 N, G051918N, 3G043219]
- Ghent University [BOF14-GOA-019, IOP 01/O3618]
- Deutsche Forschungsgemeinschaft (DFG) [CO 291/5-2]
- German Federal Ministry of Education and Research (BMBF) through the Joint Project Modelling ALS Disease In Vitro (MAIV) [01EK1611B]
- VIP+ programme NEUROPROTEKT [03VP04260]
- Bavarian Ministry of Economic Affairs, Regional Development and Energy (StMWi)
Ask authors/readers for more resources
Ferroptosis is a recently recognized cell death modality that is morphologically, biochemically and genetically distinct from other forms of cell death and that has emerged to play an important role in cancer biology. Recent discoveries have highlighted the metabolic plasticity of cancer cells and have provided intriguing insights into how metabolic rewiring is a critical event for the persistence, dedifferentiation and expansion of cancer cells. In some cases, this metabolic reprogramming has been linked to an acquired sensitivity to ferroptosis, thus opening up new opportunities to treat therapy-insensitive tumours. However, it is not yet clear what metabolic determinants are critical for therapeutic resistance and evasion of immune surveillance. Therefore, a better understanding of the processes that regulate ferroptosis sensitivity should ultimately aid in the discovery of novel therapeutic strategies to improve cancer treatment. In this Perspectives article, we provide an overview of the known mechanisms that regulate sensitivity to ferroptosis in cancer cells and how the modulation of metabolic pathways controlling ferroptosis might reshape the tumour niche, leading to an immunosuppressive microenvironment that promotes tumour growth and progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available