Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 6, Issue 4, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2018.1558682
Keywords
DNA damage; innate immunity; etoposide; STING; IFI16
Categories
Funding
- Medical Research Council [MR/K00655X/1]
- European Commission [MC-CIG 631718]
- North West Cancer Research [CR1140]
- MRC [MR/K00655X/2, MR/K00655X/1] Funding Source: UKRI
- Medical Research Council [MR/K00655X/2, MR/K00655X/1] Funding Source: researchfish
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Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes).
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