Journal
ADVANCED BIOSYSTEMS
Volume 3, Issue 5, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adbi.201900008
Keywords
cancer diagnosis; cancer therapy; exosomes; intercellular communication; tumor pathogenesis
Categories
Funding
- National Natural Science Foundation of China [21622608]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB29040303]
- National Key R&D Program of China [2017YFA0207900]
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As natural secreted nanovesicles through the endolysosomal pathway, exosomes have attracted increasing attention over the past decades. An overwhelming number of studies have provided evidence for the intriguing roles that exosomes play in intercellular communication. They are widely involved in the transmission of biomolecule cargos between original cells and neighboring/distant cells in normal physiological processes. In addition, it has also been demonstrated that exosomes play vital roles in multiple biological pathways in the development of numerous diseases including cancer. Moreover, both natural and modified exosomes showed promising potential in serving as a versatile nanoplatform for cancer diagnosis and cancer therapy. This review aims to present a comprehensive and critical overview on the recent advances in exosome nanoscience and nanotechnology, ranging from their biogenesis, secretion, isolation, and biological function in tumor pathogenesis to their extensive antitumor applications.
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