Synthesis, characterization and biological evaluation of fluorescent biphenyl-furocoumarin derivatives

A series of new biphenyl furocoumarin derivatives were synthesized via Suzuki Miyaura reaction as a critical step. The structures were characterized by NMR, IR and HRMS. All the derivatives presented vasodilatory activity in different degree, especially 6b. Photoelectric properties of all derivatives were investigated by fluorescence, including the variation in different solvents and various pH of 6b. All the ground state molecular geometries from 6a-6j are fully optimized by Density Functional Theory (DFT) on gas phase, which was in accordance with the fluorescence detection. The results suggested cornpounds with biphenyl furocoumarin skeleton would serve as promising vasodilatory candidates as well as fluorescent indicators. (C) 2014 Elsevier Ltd. All rights reserved.