Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 50, Pages 7175-7178Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc03056e
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Funding
- National Science Fund for Distinguished Young Scholars [31825012]
- National Key Research and Development Program of China [2017YFC1103502, 2018YFC1003401]
- NSFC [21875116]
- Tianjin Science Fund for Distinguished Young Scholars [17JCJQJC44900]
- Natural Science Foundation of Jiangsu Province [BK20181368]
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The identification and removal of senescent cells is very important to improve human health and prolong life. In this study, we introduced a novel strategy of beta-galactosidase (beta-Gal) instructed peptide self-assembly to selectively form nanofibers and hydrogels in senescent cells. We demonstrated that the in situ formed nanofibers could alleviate endothelial cell senescence by reducing p53, p21, and p16(INK4a) expression levels. We also demonstrated that our strategy could selectively remove senescent endothelial cells by inducing cell apoptosis, with an increase in the BAX/BCL-2 ratio and caspase-3 expression. Our study reports the first example of enzyme-instructed self-assembly (EISA) by a sugar hydrolase, which may lead to the development of supramolecular nanomaterials for the diagnosis and treatment of many diseases, such as cancer, and for other applications, such as wound healing and senescence.
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