Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 50, Pages 7235-7238Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc02186h
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An NMR approach based on parahydrogen hyperpolarization is presented to detect and resolve specific classes of metabolites in complex biomixtures at down to nanomolar concentrations. We demonstrate our method on solid phase extracts of urine, by simultaneously observing hundreds of metabolites well below the limits of detection of thermal NMR.
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